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Psychedelics Due to the small number of patients involved, conclusions about overall efficacy cannot be drawn, however Phase II trials provide guidance on how to optimally design larger Phase III trials to test the drug’s safety and efficacy. A self-reported measure, in the form of a survey, used by researchers to understand whether a participant had a mystical experience (e.g., after ingesting psychedelics in a study). The conventional version, which has 43 items, was developed by Walter Pahnke and William Richards in the 1960s. A revised version, including 30 items, was validated in 2015 (Barrett et al., 2015) and is often used in contemporary research. Monoamine oxidase inhibitors change the levels of the brain chemicals norepinephrine, serotonin and dopamine called neurotransmitters which act to stabilize mood. This dose of 5-HTP produced the HTR only in WT mice, and the dose of 5-MeO-DMT induced the greatest HTR in both genotypes. Treating WT mice with 5-HTP led to phosphorylat